Epigenetic suppression of EGFR signaling in G-CIMP+ glioblastomas

The intrinsic signaling cascades and cell states associated with the Glioma CpG Island Methylator Phenotype (G-CIMP) remain poorly understood. Using published mRNA signatures associated with EGFR activation, we demonstrate that G-CIMP+ tumors harbor decreased EGFR signaling using three independent d...

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Detalles Bibliográficos
Autores principales: Li, Jie, Taich, Zachary J., Goyal, Amit, Gonda, David, Akers, Johnny, Adhikari, Bandita, Patel, Kunal, Vandenberg, Scott, Yan, Wei, Bao, Zhaoshi, Carter, Bob S., Wang, Renzhi, Mao, Ying, Jiang, Tao, Chen, Clark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202127/
https://www.ncbi.nlm.nih.gov/pubmed/25277177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202127/
https://www.ncbi.nlm.nih.gov/pubmed/25277177

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