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βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy

In mammals, cell cycle progression is controlled by cyclin-dependent kinases, among which CDK1 plays important roles in the regulation of the G2/M transition, G1 progression and G1/S transition. CDK1 is highly regulated by its association to cyclins, phosphorylation and dephosphorylation, changes in...

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Detalles Bibliográficos
Autores principales:	Herrero-Ruiz, Joaquín, Mora-Santos, Mar, Giráldez, Servando, Sáez, Carmen, Japón, Miguel Á., Tortolero, Maria, Romero, Francisco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202144/ https://www.ncbi.nlm.nih.gov/pubmed/25149538

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