FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics

Focal adhesion kinase (FAK) is up-regulated in thyroid cancer and small molecule FAK scaffolding inhibitor, Y15, was shown to decrease cancer growth in vitro and in vivo. We sought to test the effectiveness of Y15 in thyroid cancer cell lines, profile gene expression with Y15 compared with clinical...

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Detalles Bibliográficos
Autores principales: O'Brien, Shalana, Golubovskaya, Vita M., Conroy, Jeffrey, Liu, Song, Wang, Dan, Liu, Biao, Cance, William G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202172/
https://www.ncbi.nlm.nih.gov/pubmed/25277206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202172/
https://www.ncbi.nlm.nih.gov/pubmed/25277206

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