Effects of Chk1 inhibition on the temporal duration of radiation-induced G2 arrest in HeLa cells

Chk1 inhibitor acts as a potent radiosensitizer in p53-deficient tumor cells by abrogating the G2/M checkpoint. However, the effects of Chk1 inhibitor on the duration of G2 arrest have not been precisely analyzed. To address this issue, we utilized a cell-cycle visualization system, fluorescent ubiq...

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Detalles Bibliográficos
Autores principales: Nahar, Kamrun, Goto, Tatsuaki, Kaida, Atsushi, Deguchi, Shifumi, Miura, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202296/
https://www.ncbi.nlm.nih.gov/pubmed/24894074
http://dx.doi.org/10.1093/jrr/rru038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202296/
https://www.ncbi.nlm.nih.gov/pubmed/24894074
http://dx.doi.org/10.1093/jrr/rru038

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