Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?

Genetic polymorphisms in the APOE ɛ and TOMM40 ‘523' poly-T repeat gene loci have been associated with significantly increased risk of Alzheimer's disease. This study investigated the independent effects of these polymorphisms on human cognitive ageing, and the extent to which nominally si...

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Detalles Bibliográficos
Autores principales: Lyall, D M, Harris, S E, Bastin, M E, Muñoz Maniega, S, Murray, C, Lutz, M W, Saunders, A M, Roses, A D, Valdés Hernández, M del C, Royle, N A, Starr, J M, Porteous, D J, Wardlaw, J M, Deary, I J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203017/
https://www.ncbi.nlm.nih.gov/pubmed/25247594
http://dx.doi.org/10.1038/tp.2014.89

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203017/
https://www.ncbi.nlm.nih.gov/pubmed/25247594
http://dx.doi.org/10.1038/tp.2014.89

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