Identification of a novel polyprenylated acylphloroglucinol-derived SIRT1 inhibitor with cancer-specific anti-proliferative and invasion-suppressing activities

SIRT1, a class III histone deacetylase, plays a critical role in regulating cancer cell growth, migration and invasion, which makes it a potential target for cancer therapeutics. In this study, we screened derivatives of several groups of natural products and identified a novel SIRT1 inhibitor JQ-10...

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Detalles Bibliográficos
Autores principales: ZHU, LIJIA, QI, JI, CHIAO, CHRISTINE YA-CHI, ZHANG, QIANG, PORCO, JOHN A., FALLER, DOUGLAS V., DAI, YAN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203335/
https://www.ncbi.nlm.nih.gov/pubmed/25189993
http://dx.doi.org/10.3892/ijo.2014.2639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203335/
https://www.ncbi.nlm.nih.gov/pubmed/25189993
http://dx.doi.org/10.3892/ijo.2014.2639

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