Salvaging hope: Is increasing NAD(+) a key to treating mitochondrial myopathy?

Mitochondrial diseases can arise from mutations either in mitochondrial DNA or in nuclear DNA encoding mitochondrially destined proteins. Currently, there is no cure for these diseases although treatments to ameliorate a subset of the symptoms are being developed. In this issue of EMBO Molecular Med...

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Autores principales: Lightowlers, Robert N, Chrzanowska-Lightowlers, Zofia MA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203349/
https://www.ncbi.nlm.nih.gov/pubmed/24838280
http://dx.doi.org/10.15252/emmm.201404179
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author Lightowlers, Robert N
Chrzanowska-Lightowlers, Zofia MA
author_facet Lightowlers, Robert N
Chrzanowska-Lightowlers, Zofia MA
author_sort Lightowlers, Robert N
collection PubMed
description Mitochondrial diseases can arise from mutations either in mitochondrial DNA or in nuclear DNA encoding mitochondrially destined proteins. Currently, there is no cure for these diseases although treatments to ameliorate a subset of the symptoms are being developed. In this issue of EMBO Molecular Medicine, Khan et al (2014) use a mouse model to test the efficacy of a simple dietary supplement of nicotinamide riboside to treat and prevent mitochondrial myopathies.
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spelling pubmed-42033492014-11-12 Salvaging hope: Is increasing NAD(+) a key to treating mitochondrial myopathy? Lightowlers, Robert N Chrzanowska-Lightowlers, Zofia MA EMBO Mol Med Closeup Mitochondrial diseases can arise from mutations either in mitochondrial DNA or in nuclear DNA encoding mitochondrially destined proteins. Currently, there is no cure for these diseases although treatments to ameliorate a subset of the symptoms are being developed. In this issue of EMBO Molecular Medicine, Khan et al (2014) use a mouse model to test the efficacy of a simple dietary supplement of nicotinamide riboside to treat and prevent mitochondrial myopathies. Blackwell Publishing Ltd 2014-06 2014-05-16 /pmc/articles/PMC4203349/ /pubmed/24838280 http://dx.doi.org/10.15252/emmm.201404179 Text en © 2014 The Authors. Published under the terms of the CC BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Closeup
Lightowlers, Robert N
Chrzanowska-Lightowlers, Zofia MA
Salvaging hope: Is increasing NAD(+) a key to treating mitochondrial myopathy?
title Salvaging hope: Is increasing NAD(+) a key to treating mitochondrial myopathy?
title_full Salvaging hope: Is increasing NAD(+) a key to treating mitochondrial myopathy?
title_fullStr Salvaging hope: Is increasing NAD(+) a key to treating mitochondrial myopathy?
title_full_unstemmed Salvaging hope: Is increasing NAD(+) a key to treating mitochondrial myopathy?
title_short Salvaging hope: Is increasing NAD(+) a key to treating mitochondrial myopathy?
title_sort salvaging hope: is increasing nad(+) a key to treating mitochondrial myopathy?
topic Closeup
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203349/
https://www.ncbi.nlm.nih.gov/pubmed/24838280
http://dx.doi.org/10.15252/emmm.201404179
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