Biochemical Analysis of Six Genetic Variants of Error-Prone Human DNA Polymerase ι Involved in Translesion DNA Synthesis

[Image: see text] DNA polymerase (pol) ι is the most error-prone among the Y-family polymerases that participate in translesion synthesis (TLS). Pol ι can bypass various DNA lesions, e.g., N(2)-ethyl(Et)G, O(6)-methyl(Me)G, 8-oxo-7,8-dihydroguanine (8-oxoG), and an abasic site, though frequently wit...

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Detalles Bibliográficos
Autores principales: Kim, Jinsook, Song, Insil, Jo, Ara, Shin, Joo-Ho, Cho, Hana, Eoff, Robert L., Guengerich, F. Peter, Choi, Jeong-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203391/
https://www.ncbi.nlm.nih.gov/pubmed/25162224
http://dx.doi.org/10.1021/tx5002755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203391/
https://www.ncbi.nlm.nih.gov/pubmed/25162224
http://dx.doi.org/10.1021/tx5002755

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