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Analysis of a Malondialdehyde–Deoxyguanosine Adduct in Human Leukocyte DNA by Liquid Chromatography Nanoelectrospray–High-Resolution Tandem Mass Spectrometry

[Image: see text] Malondialdehyde (MDA), an endogenous genotoxic product formed upon lipid peroxidation and prostaglandin biosynthesis, can react with DNA to form stable adducts. These adducts may contribute to the development of such inflammation-mediated diseases as cancer and cardiovascular and n...

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Detalles Bibliográficos
Autores principales: Ma, Bin, Villalta, Peter W., Balbo, Silvia, Stepanov, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203394/
https://www.ncbi.nlm.nih.gov/pubmed/25181548
http://dx.doi.org/10.1021/tx5002699