Optimization of Chemical Functionalities of Indole-2-carboxamides To Improve Allosteric Parameters for the Cannabinoid Receptor 1 (CB1)

[Image: see text] 5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide (1; ORG27569) is a prototypical allosteric modulator for the cannabinoid type 1 receptor (CB1). Here, we reveal key structural requirements of indole-2-carboxamides for allosteric modulation of CB1: a critical...

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Detalles Bibliográficos
Autores principales: Khurana, Leepakshi, Ali, Hamed I., Olszewska, Teresa, Ahn, Kwang H., Damaraju, Aparna, Kendall, Debra A., Lu, Dai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203403/
https://www.ncbi.nlm.nih.gov/pubmed/24635495
http://dx.doi.org/10.1021/jm5000112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203403/
https://www.ncbi.nlm.nih.gov/pubmed/24635495
http://dx.doi.org/10.1021/jm5000112

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