Targeting the GPIbα Binding Site of Thrombin To Simultaneously Induce Dual Anticoagulant and Antiplatelet Effects

[Image: see text] Exosite 2 of human thrombin contributes to two opposing pathways, the anticoagulant pathway and the platelet aggregation pathway. We reasoned that an exosite 2 directed allosteric thrombin inhibitor should simultaneously induce anticoagulant and antiplatelet effects. To assess this...

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Detalles Bibliográficos
Autores principales: Mehta, Akul Y., Thakkar, Jay N., Mohammed, Bassem M., Martin, Erika J., Brophy, Donald F., Kishimoto, Takao, Desai, Umesh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203406/
https://www.ncbi.nlm.nih.gov/pubmed/24635452
http://dx.doi.org/10.1021/jm4020026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203406/
https://www.ncbi.nlm.nih.gov/pubmed/24635452
http://dx.doi.org/10.1021/jm4020026

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