LIF negatively regulates tumor suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers

Leukemia inhibitory factor (LIF) has been recently identified as a p53 target gene, which mediates the role of p53 in maternal implantation under normal physiological conditions. Here, we report that LIF is a negative regulator of p53; LIF downregulates p53 protein levels and function in human color...

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Detalles Bibliográficos
Autores principales: Yu, Haiyang, Yue, Xuetian, Zhao, Yuhan, Li, Xiaoyan, Wu, Lihua, Zhang, Cen, Liu, Zhen, Lin, Kevin, Xu-Monette, Zijun Y., Young, Ken H., Liu, Juan, Shen, Zhiyuan, Feng, Zhaohui, Hu, Wenwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203416/
https://www.ncbi.nlm.nih.gov/pubmed/25323535
http://dx.doi.org/10.1038/ncomms6218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203416/
https://www.ncbi.nlm.nih.gov/pubmed/25323535
http://dx.doi.org/10.1038/ncomms6218

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