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Autophagy is increased in prostate cancer cells over-expressing acid ceramidase and enhances resistance to C(6)-ceramide
Acid ceramidase (AC) over-expression has been observed in prostate cancer cell lines and primary tumors, and contributes to resistance to chemotherapy and radiation. The consequence of AC over-expression is the ability to convert ceramide, which is often produced as a pro-apoptotic response to stres...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203650/ https://www.ncbi.nlm.nih.gov/pubmed/21116286 http://dx.doi.org/10.1038/pcan.2010.47 |