The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease

Dysregulated endoplasmic reticulum (ER) calcium (Ca(2+)) signaling is reported to play an important role in Alzheimer disease (AD) pathogenesis. The role of ER Ca(2+) release channels, the ryanodine receptors (RyanRs), has been extensively studied in AD models and RyanR expression and activity are u...

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Detalles Bibliográficos
Autores principales: Liu, Jie, Supnet, Charlene, Sun, Suya, Zhang, Hua, Good, Levi, Popugaeva, Elena, Bezprozvanny, Ilya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203752/
https://www.ncbi.nlm.nih.gov/pubmed/24476841
http://dx.doi.org/10.4161/chan.27471
Descripción
Sumario:Dysregulated endoplasmic reticulum (ER) calcium (Ca(2+)) signaling is reported to play an important role in Alzheimer disease (AD) pathogenesis. The role of ER Ca(2+) release channels, the ryanodine receptors (RyanRs), has been extensively studied in AD models and RyanR expression and activity are upregulated in the brains of various familial AD (FAD) models. The objective of this study was to utilize a genetic approach to evaluate the importance of RyanR type 3 (RyanR3) in the context of AD pathology.

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