The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease

Dysregulated endoplasmic reticulum (ER) calcium (Ca(2+)) signaling is reported to play an important role in Alzheimer disease (AD) pathogenesis. The role of ER Ca(2+) release channels, the ryanodine receptors (RyanRs), has been extensively studied in AD models and RyanR expression and activity are u...

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Detalles Bibliográficos
Autores principales: Liu, Jie, Supnet, Charlene, Sun, Suya, Zhang, Hua, Good, Levi, Popugaeva, Elena, Bezprozvanny, Ilya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203752/
https://www.ncbi.nlm.nih.gov/pubmed/24476841
http://dx.doi.org/10.4161/chan.27471
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author Liu, Jie
Supnet, Charlene
Sun, Suya
Zhang, Hua
Good, Levi
Popugaeva, Elena
Bezprozvanny, Ilya
author_facet Liu, Jie
Supnet, Charlene
Sun, Suya
Zhang, Hua
Good, Levi
Popugaeva, Elena
Bezprozvanny, Ilya
author_sort Liu, Jie
collection PubMed
description Dysregulated endoplasmic reticulum (ER) calcium (Ca(2+)) signaling is reported to play an important role in Alzheimer disease (AD) pathogenesis. The role of ER Ca(2+) release channels, the ryanodine receptors (RyanRs), has been extensively studied in AD models and RyanR expression and activity are upregulated in the brains of various familial AD (FAD) models. The objective of this study was to utilize a genetic approach to evaluate the importance of RyanR type 3 (RyanR3) in the context of AD pathology.
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spelling pubmed-42037522015-06-23 The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease Liu, Jie Supnet, Charlene Sun, Suya Zhang, Hua Good, Levi Popugaeva, Elena Bezprozvanny, Ilya Channels (Austin) Research Paper Dysregulated endoplasmic reticulum (ER) calcium (Ca(2+)) signaling is reported to play an important role in Alzheimer disease (AD) pathogenesis. The role of ER Ca(2+) release channels, the ryanodine receptors (RyanRs), has been extensively studied in AD models and RyanR expression and activity are upregulated in the brains of various familial AD (FAD) models. The objective of this study was to utilize a genetic approach to evaluate the importance of RyanR type 3 (RyanR3) in the context of AD pathology. Landes Bioscience 2014-05-01 2014-01-29 /pmc/articles/PMC4203752/ /pubmed/24476841 http://dx.doi.org/10.4161/chan.27471 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Research Paper
Liu, Jie
Supnet, Charlene
Sun, Suya
Zhang, Hua
Good, Levi
Popugaeva, Elena
Bezprozvanny, Ilya
The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease
title The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease
title_full The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease
title_fullStr The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease
title_full_unstemmed The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease
title_short The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease
title_sort role of ryanodine receptor type 3 in a mouse model of alzheimer disease
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203752/
https://www.ncbi.nlm.nih.gov/pubmed/24476841
http://dx.doi.org/10.4161/chan.27471
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