Enantiomerically pure amino-alcohol quinolines: in vitro anti-malarial activity in combination with dihydroartemisinin, cytotoxicity and in vivo efficacy in a Plasmodium berghei mouse model

BACKGROUND: As resistance to marketed anti-malarial drugs continues to spread, the need for new molecules active on Plasmodium falciparum-resistant strains grows. Pure (S) enantiomers of amino-alcohol quinolines previously displayed a good in vitro anti-malarial activity. Therefore, a more thorough...

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Detalles Bibliográficos
Autores principales: Mullié, Catherine, Taudon, Nicolas, Degrouas, Camille, Jonet, Alexia, Pascual, Aurélie, Agnamey, Patrice, Sonnet, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203867/
https://www.ncbi.nlm.nih.gov/pubmed/25319003
http://dx.doi.org/10.1186/1475-2875-13-407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203867/
https://www.ncbi.nlm.nih.gov/pubmed/25319003
http://dx.doi.org/10.1186/1475-2875-13-407

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