Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo–activated cells

Variable (V) genes of immunoglobulins undergo somatic hypermutation by activation-induced deaminase (AID) to generate amino acid substitutions that encode antibodies with increased affinity for antigen. Hypermutation is restricted to germinal center B cells and cannot be recapitulated in ex vivo–act...

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Detalles Bibliográficos
Autores principales: Maul, Robert W., Cao, Zheng, Venkataraman, Lakshmi, Giorgetti, Carol A., Press, Joan L., Denizot, Yves, Du, Hansen, Sen, Ranjan, Gearhart, Patricia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203944/
https://www.ncbi.nlm.nih.gov/pubmed/25288395
http://dx.doi.org/10.1084/jem.20131512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203944/
https://www.ncbi.nlm.nih.gov/pubmed/25288395
http://dx.doi.org/10.1084/jem.20131512

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