microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells

T cell receptor (TCR) signals can elicit full activation with acquisition of effector functions or a state of anergy. Here, we ask whether microRNAs affect the interpretation of TCR signaling. We find that Dicer-deficient CD4 T cells fail to correctly discriminate between activating and anergy-induc...

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Detalles Bibliográficos
Autores principales: Marcais, Antoine, Blevins, Rory, Graumann, Johannes, Feytout, Amelie, Dharmalingam, Gopuraja, Carroll, Thomas, Amado, Inês F., Bruno, Ludovica, Lee, Keunwook, Walzer, Thierry, Mann, Matthias, Freitas, Antonio A., Boothby, Mark, Fisher, Amanda G., Merkenschlager, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203951/
https://www.ncbi.nlm.nih.gov/pubmed/25311506
http://dx.doi.org/10.1084/jem.20132059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203951/
https://www.ncbi.nlm.nih.gov/pubmed/25311506
http://dx.doi.org/10.1084/jem.20132059

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