Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells

BACKGROUND: Cells harboring BRCA1/BRCA2 mutations are hypersensitive to inhibition of poly(ADP-ribose) polymerase-1 (PARP-1). We recently showed that interference with PARP-1 activity by NU1025 is strongly cytotoxic for BRCA1-positive BT-20 cells but not BRCA1-deficient SKBr-3 cells. These unexpecte...

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Detalles Bibliográficos
Autores principales: Węsierska-Gądek, Józefa, Heinzl, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Cancer Prevention 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204161/
https://www.ncbi.nlm.nih.gov/pubmed/25337581
http://dx.doi.org/10.15430/JCP.2014.19.2.125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204161/
https://www.ncbi.nlm.nih.gov/pubmed/25337581
http://dx.doi.org/10.15430/JCP.2014.19.2.125

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