Identification of a metabolic biomarker panel in rats for prediction of acute and idiosyncratic hepatotoxicity

It has been estimated that 10% of acute liver failure is due to “idiosyncratic hepatotoxicity”. The inability to identify such compounds with classical preclinical markers of hepatotoxicity has driven the need to discover a mechanism-based biomarker panel for hepatotoxicity. Seven compounds were inc...

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Detalles Bibliográficos
Autores principales: Sun, Jinchun, Slavov, Svetoslav, Schnackenberg, Laura K., Ando, Yosuke, Greenhaw, James, Yang, Xi, Salminen, William, Mendrick, Donna L., Beger, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204381/
https://www.ncbi.nlm.nih.gov/pubmed/25379137
http://dx.doi.org/10.1016/j.csbj.2014.08.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204381/
https://www.ncbi.nlm.nih.gov/pubmed/25379137
http://dx.doi.org/10.1016/j.csbj.2014.08.001

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