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Identification of a metabolic biomarker panel in rats for prediction of acute and idiosyncratic hepatotoxicity
It has been estimated that 10% of acute liver failure is due to “idiosyncratic hepatotoxicity”. The inability to identify such compounds with classical preclinical markers of hepatotoxicity has driven the need to discover a mechanism-based biomarker panel for hepatotoxicity. Seven compounds were inc...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204381/ https://www.ncbi.nlm.nih.gov/pubmed/25379137 http://dx.doi.org/10.1016/j.csbj.2014.08.001 |