Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

Dysfunction or death of pancreatic β cells underlies both types of diabetes. This functional decline begins with β cell stress and de-differentiation. Current drugs for type 2 diabetes (T2D) lower blood glucose levels but they do not directly alleviate β cell stress nor prevent, let alone reverse, β...

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Detalles Bibliográficos
Autores principales: Blum, Barak, Roose, Adam N, Barrandon, Ornella, Maehr, René, Arvanites, Anthony C, Davidow, Lance S, Davis, Jeffrey C, Peterson, Quinn P, Rubin, Lee L, Melton, Douglas A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204634/
https://www.ncbi.nlm.nih.gov/pubmed/25233132
http://dx.doi.org/10.7554/eLife.02809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204634/
https://www.ncbi.nlm.nih.gov/pubmed/25233132
http://dx.doi.org/10.7554/eLife.02809

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