An integrated computational approach can classify VHL missense mutations according to risk of clear cell renal carcinoma

Mutations in the von Hippel–Lindau (VHL) gene are pathogenic in VHL disease, congenital polycythaemia and clear cell renal carcinoma (ccRCC). pVHL forms a ternary complex with elongin C and elongin B, critical for pVHL stability and function, which interacts with Cullin-2 and RING-box protein 1 to t...

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Detalles Bibliográficos
Autores principales: Gossage, Lucy, Pires, Douglas E. V., Olivera-Nappa, Álvaro, Asenjo, Juan, Bycroft, Mark, Blundell, Tom L., Eisen, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204774/
https://www.ncbi.nlm.nih.gov/pubmed/24969085
http://dx.doi.org/10.1093/hmg/ddu321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204774/
https://www.ncbi.nlm.nih.gov/pubmed/24969085
http://dx.doi.org/10.1093/hmg/ddu321

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