An Integrated Model of Transcription Factor Diffusion Shows the Importance of Intersegmental Transfer and Quaternary Protein Structure for Target Site Finding

We present a computational model of transcription factor motion that explains both the observed rapid target finding of transcription factors, and how this motion influences protein and genome structure. Using the Smoldyn software, we modelled transcription factor motion arising from a combination o...

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Detalles Bibliográficos
Autores principales: Schmidt, Hugo G., Sewitz, Sven, Andrews, Steven S., Lipkow, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204827/
https://www.ncbi.nlm.nih.gov/pubmed/25333780
http://dx.doi.org/10.1371/journal.pone.0108575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204827/
https://www.ncbi.nlm.nih.gov/pubmed/25333780
http://dx.doi.org/10.1371/journal.pone.0108575

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