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DNA Damage Enhanced by the Attenuation of SLD5 Delays Cell Cycle Restoration in Normal Cells but Not in Cancer Cells

SLD5 is a member of the GINS complex composed of PSF1, PSF2, PSF3 and SLD5, playing a critical role in the formation of the DNA replication fork with CDC45 in yeast. Previously, we had isolated a PSF1 orthologue from a murine hematopoietic stem cell DNA library and were then able to identify ortholo...

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Detalles Bibliográficos
Autores principales: Gong, Zhi-Yuan, Kidoya, Hiroyasu, Mohri, Tomomi, Han, Yinglu, Takakura, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204874/
https://www.ncbi.nlm.nih.gov/pubmed/25334017
http://dx.doi.org/10.1371/journal.pone.0110483