Catalytic Core of Human Topoisomerase IIα: Insights into Enzyme–DNA Interactions and Drug Mechanism

[Image: see text] Coordination between the N-terminal gate and the catalytic core of topoisomerase II allows the proper capture, cleavage, and transport of DNA during the catalytic cycle. Because the activities of these domains are tightly linked, it has been difficult to discern their individual co...

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Detalles Bibliográficos
Autores principales: Lindsey, R. Hunter, Pendleton, MaryJean, Ashley, Rachel E., Mercer, Susan L., Deweese, Joseph E., Osheroff, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204876/
https://www.ncbi.nlm.nih.gov/pubmed/25280269
http://dx.doi.org/10.1021/bi5010816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204876/
https://www.ncbi.nlm.nih.gov/pubmed/25280269
http://dx.doi.org/10.1021/bi5010816

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