Expression of the IL-7 Receptor Alpha-Chain Is Down Regulated on the Surface of CD4 T-Cells by the HIV-1 Tat Protein

HIV infection elicits defects in CD4 T-cell homeostasis in both a quantitative and qualitative manner. Interleukin-7 (IL-7) is essential to T-cell homeostasis and several groups have shown reduced levels of the IL-7 receptor alpha-chain (CD127) on both CD4 and CD8 T-cells in viremic HIV+ patients. W...

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Detalles Bibliográficos
Autores principales: McLaughlin, Denny, Faller, Elliott, Sugden, Scott, MacPherson, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205093/
https://www.ncbi.nlm.nih.gov/pubmed/25333710
http://dx.doi.org/10.1371/journal.pone.0111193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205093/
https://www.ncbi.nlm.nih.gov/pubmed/25333710
http://dx.doi.org/10.1371/journal.pone.0111193

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