Imaging the Intracellular Distribution of Tyrosine Kinase Inhibitors in Living Cells with Quantitative Hyperspectral Stimulated Raman Scattering

ABL1 tyrosine-kinase inhibitors (TKI) are a front-line therapy for chronic myelogenous leukemia and represent the best known examples of targeted cancer therapeutics. However, the dynamic uptake of low molecular weight TKIs into cells and their intracellular behavior is largely unknown due to the di...

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Detalles Bibliográficos
Autores principales: Fu, Dan, Zhou, Jing, Zhu, Wenjing Suzanne, Manley, Paul W., Wang, Y. Karen, Hood, Tami, Wylie, Andrew, Xie, X. Sunney
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205760/
https://www.ncbi.nlm.nih.gov/pubmed/24950332
http://dx.doi.org/10.1038/nchem.1961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205760/
https://www.ncbi.nlm.nih.gov/pubmed/24950332
http://dx.doi.org/10.1038/nchem.1961

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