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The effect of clozapine on mRNA expression for genes encoding G protein-coupled receptors and the protein components of clathrin-mediated endocytosis
OBJECTIVES: Clathrin-mediated endocytosis (CME) is an intracellular trafficking mechanism for packaging cargo, including G protein-coupled receptors (GPCRs), into clathrin-coated vesicles (CCVs). The antipsychotic chlorpromazine inhibits CCV assembly of adaptor protein AP2 whereas clozapine increase...
Autores principales: | Sharp, Sally I., Hu, Ying, Weymer, Jon F., Rizig, Mie, McQuillin, Andrew, Hunt, Stephen P., Gurling, Hugh M.D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206381/ https://www.ncbi.nlm.nih.gov/pubmed/23811784 http://dx.doi.org/10.1097/YPG.0b013e32835fe51d |
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