Transcription of Hepatitis B Virus Covalently Closed Circular DNA Is Regulated by CpG Methylation during Chronic Infection

The persistence of hepatitis B virus (HBV) infection is maintained by the nuclear viral covalently closed circular DNA (cccDNA), which serves as transcription template for viral mRNAs. Previous studies suggested that cccDNA contains methylation-prone CpG islands, and that the minichromosome structur...

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Detalles Bibliográficos
Autores principales: Zhang, Yongmei, Mao, Richeng, Yan, Ran, Cai, Dawei, Zhang, Yijun, Zhu, Haoxiang, Kang, Yaoyue, Liu, Hongyan, Wang, Jinyu, Qin, Yanli, Huang, Yuxian, Guo, Haitao, Zhang, Jiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206413/
https://www.ncbi.nlm.nih.gov/pubmed/25337821
http://dx.doi.org/10.1371/journal.pone.0110442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206413/
https://www.ncbi.nlm.nih.gov/pubmed/25337821
http://dx.doi.org/10.1371/journal.pone.0110442

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