Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

[Image: see text] E3 ubiquitin ligases are attractive targets in the ubiquitin–proteasome system, however, the development of small-molecule ligands has been rewarded with limited success. The von Hippel–Lindau protein (pVHL) is the substrate recognition subunit of the VHL E3 ligase that targets HIF...

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Detalles Bibliográficos
Autores principales: Galdeano, Carles, Gadd, Morgan S., Soares, Pedro, Scaffidi, Salvatore, Van Molle, Inge, Birced, Ipek, Hewitt, Sarah, Dias, David M., Ciulli, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207132/
https://www.ncbi.nlm.nih.gov/pubmed/25166285
http://dx.doi.org/10.1021/jm5011258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207132/
https://www.ncbi.nlm.nih.gov/pubmed/25166285
http://dx.doi.org/10.1021/jm5011258

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