Translational potential of a mouse in vitro bioassay in predicting gastrointestinal adverse drug reactions in Phase I clinical trials

BACKGROUND: Motility-related gastrointestinal (GI) adverse drug reactions (GADRs) such as diarrhea and constipation are a common and deleterious feature associated with drug development. Novel biomarkers of GI function are therefore required to aid decision making on the GI liability of compounds in...

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Detalles Bibliográficos
Autores principales: Keating, C, Ewart, L, Grundy, L, Valentin, JP, Grundy, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207192/
https://www.ncbi.nlm.nih.gov/pubmed/24813024
http://dx.doi.org/10.1111/nmo.12349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207192/
https://www.ncbi.nlm.nih.gov/pubmed/24813024
http://dx.doi.org/10.1111/nmo.12349

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