Cardiac arrhythmia induced by genetic silencing of “funny” (f) channels is rescued by GIRK4 inactivation

The mechanisms underlying cardiac automaticity are still incompletely understood and controversial. Here we report the complete conditional and time-controlled silencing of the "funny" current (I(f)) by expression of a dominant-negative, non-conductive HCN4-channel subunit (hHCN4-AYA). Hea...

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Detalles Bibliográficos
Autores principales: Mesirca, Pietro, Alig, Jacqueline, Torrente, Angelo G., Müller, Jana Christina, Marger, Laurine, Rollin, Anne, Marquilly, Claire, Vincent, Anne, Dubel, Stefan, Bidaud, Isabelle, Fernandez, Anne, Seniuk, Anika, Engeland, Birgit, Singh, Jasmin, Miquerol, Lucile, Ehmke, Heimo, Eschenhagen, Thomas, Nargeot, Joel, Wickman, Kevin, Isbrandt, Dirk, Mangoni, Matteo E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207211/
https://www.ncbi.nlm.nih.gov/pubmed/25144323
http://dx.doi.org/10.1038/ncomms5664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207211/
https://www.ncbi.nlm.nih.gov/pubmed/25144323
http://dx.doi.org/10.1038/ncomms5664

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