Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease

The amyloid hypothesis has driven drug development strategies for Alzheimer's disease for over 20 years. We review why accumulation of amyloid-beta (Aβ) oligomers is generally considered causal for synaptic loss and neurodegeneration in AD. We elaborate on and update arguments for and against t...

Descripción completa

Detalles Bibliográficos
Autores principales: Morris, Gary P, Clark, Ian A, Vissel, Bryce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207354/
https://www.ncbi.nlm.nih.gov/pubmed/25231068
http://dx.doi.org/10.1186/s40478-014-0135-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207354/
https://www.ncbi.nlm.nih.gov/pubmed/25231068
http://dx.doi.org/10.1186/s40478-014-0135-5

Ejemplares similares