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Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease
The amyloid hypothesis has driven drug development strategies for Alzheimer's disease for over 20 years. We review why accumulation of amyloid-beta (Aβ) oligomers is generally considered causal for synaptic loss and neurodegeneration in AD. We elaborate on and update arguments for and against t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207354/ https://www.ncbi.nlm.nih.gov/pubmed/25231068 http://dx.doi.org/10.1186/s40478-014-0135-5 |