Target Based Designing of Anthracenone Derivatives as Tubulin Polymerization Inhibiting Agents: 3D QSAR and Docking Approach

Novel anthracenone derivatives were designed through in silico studies including 3D QSAR, pharmacophore mapping, and molecular docking approaches. Tubulin protein was explored for the residues imperative for activity by analyzing the binding pattern of colchicine and selected compounds of anthraceno...

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Detalles Bibliográficos
Autores principales: Samad, Abdul, Naffaa, Moawiah M., Bakht, Mohammed Afroz, Malhotra, Manav, Ganaie, Majid A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207406/
https://www.ncbi.nlm.nih.gov/pubmed/25383219
http://dx.doi.org/10.1155/2014/658016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207406/
https://www.ncbi.nlm.nih.gov/pubmed/25383219
http://dx.doi.org/10.1155/2014/658016

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