A DFT and Semiempirical Model-Based Study of Opioid Receptor Affinity and Selectivity in a Group of Molecules with a Morphine Structural Core

We report the results of a search for model-based relationships between mu, delta, and kappa opioid receptor binding affinity and molecular structure for a group of molecules having in common a morphine structural core. The wave functions and local reactivity indices were obtained at the ZINDO/1 and...

Descripción completa

Detalles Bibliográficos
Autores principales: Bruna-Larenas, Tamara, Gómez-Jeria, Juan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207423/
https://www.ncbi.nlm.nih.gov/pubmed/25379287
http://dx.doi.org/10.1155/2012/682495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207423/
https://www.ncbi.nlm.nih.gov/pubmed/25379287
http://dx.doi.org/10.1155/2012/682495

Ejemplares similares