Modeling Dynamics of Cell-to-Cell Variability in TRAIL-Induced Apoptosis Explains Fractional Killing and Predicts Reversible Resistance

Isogenic cells sensing identical external signals can take markedly different decisions. Such decisions often correlate with pre-existing cell-to-cell differences in protein levels. When not neglected in signal transduction models, these differences are accounted for in a static manner, by assuming...

Descripción completa

Detalles Bibliográficos
Autores principales: Bertaux, François, Stoma, Szymon, Drasdo, Dirk, Batt, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207462/
https://www.ncbi.nlm.nih.gov/pubmed/25340343
http://dx.doi.org/10.1371/journal.pcbi.1003893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207462/
https://www.ncbi.nlm.nih.gov/pubmed/25340343
http://dx.doi.org/10.1371/journal.pcbi.1003893

Ejemplares similares