Cargando…
Systematic Dissection of Coding Exons at Single Nucleotide Resolution Supports an Additional Role in Cell-Specific Transcriptional Regulation
In addition to their protein coding function, exons can also serve as transcriptional enhancers. Mutations in these exonic-enhancers (eExons) could alter both protein function and transcription. However, the functional consequence of eExon mutations is not well known. Here, using massively parallel...
Autores principales: | Birnbaum, Ramon Y., Patwardhan, Rupali P., Kim, Mee J., Findlay, Gregory M., Martin, Beth, Zhao, Jingjing, Bell, Robert J. A., Smith, Robin P., Ku, Angel A., Shendure, Jay, Ahituv, Nadav |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207465/ https://www.ncbi.nlm.nih.gov/pubmed/25340400 http://dx.doi.org/10.1371/journal.pgen.1004592 |
Ejemplares similares
-
Massively parallel functional dissection of mammalian enhancers in vivo
por: Patwardhan, Rupali P, et al.
Publicado: (2012) -
Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution
por: Kircher, Martin, et al.
Publicado: (2019) -
Exonic enhancers: proceed with caution in exome and genome sequencing studies
por: Ahituv, Nadav
Publicado: (2016) -
Coding exons function as tissue-specific enhancers of nearby genes
por: Birnbaum, Ramon Y., et al.
Publicado: (2012) -
A systematic evaluation of the design and context dependencies of massively parallel reporter assays
por: Klein, Jason C., et al.
Publicado: (2020)