Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids

The design, synthesis, and biochemical evaluation of donepezil-pyridyl hybrids (DPHs) as multipotent cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors for the potential treatment of Alzheimer’s disease (AD) is reported. The 3D-quantitative structure-activity relationship study was used to...

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Detalles Bibliográficos
Autores principales: Bautista-Aguilera, Oscar M, Esteban, Gerard, Chioua, Mourad, Nikolic, Katarina, Agbaba, Danica, Moraleda, Ignacio, Iriepa, Isabel, Soriano, Elena, Samadi, Abdelouahid, Unzeta, Mercedes, Marco-Contelles, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207550/
https://www.ncbi.nlm.nih.gov/pubmed/25378907
http://dx.doi.org/10.2147/DDDT.S69258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207550/
https://www.ncbi.nlm.nih.gov/pubmed/25378907
http://dx.doi.org/10.2147/DDDT.S69258

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