Chitosan-decorated selenium nanoparticles as protein carriers to improve the in vivo half-life of the peptide therapeutic BAY 55-9837 for type 2 diabetes mellitus

PURPOSE: As a potential protein therapeutic for type 2 diabetes mellitus (T2DM), BAY 55-9837 is limited by poor stability and a very short half-life in vivo. The purpose of this study was to construct a novel nanostructured biomaterial by conjugating BAY 55-9837 to chitosan-decorated selenium nanopa...

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Detalles Bibliográficos
Autores principales: Rao, Lei, Ma, Yi, Zhuang, Manjiao, Luo, Tianjie, Wang, Yayu, Hong, An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207575/
https://www.ncbi.nlm.nih.gov/pubmed/25378923
http://dx.doi.org/10.2147/IJN.S67871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207575/
https://www.ncbi.nlm.nih.gov/pubmed/25378923
http://dx.doi.org/10.2147/IJN.S67871

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