Abnormal Dosage of Ultraconserved Elements Is Highly Disfavored in Healthy Cells but Not Cancer Cells

Ultraconserved elements (UCEs) are strongly depleted from segmental duplications and copy number variations (CNVs) in the human genome, suggesting that deletion or duplication of a UCE can be deleterious to the mammalian cell. Here we address the process by which CNVs become depleted of UCEs. We beg...

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Detalles Bibliográficos
Autores principales: McCole, Ruth B., Fonseka, Chamith Y., Koren, Amnon, Wu, C.-ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207606/
https://www.ncbi.nlm.nih.gov/pubmed/25340765
http://dx.doi.org/10.1371/journal.pgen.1004646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207606/
https://www.ncbi.nlm.nih.gov/pubmed/25340765
http://dx.doi.org/10.1371/journal.pgen.1004646

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