MMS Exposure Promotes Increased MtDNA Mutagenesis in the Presence of Replication-Defective Disease-Associated DNA Polymerase γ Variants

Mitochondrial DNA (mtDNA) encodes proteins essential for ATP production. Mutant variants of the mtDNA polymerase cause mutagenesis that contributes to aging, genetic diseases, and sensitivity to environmental agents. We interrogated mtDNA replication in Saccharomyces cerevisiae strains with disease-...

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Detalles Bibliográficos
Autores principales: Stumpf, Jeffrey D., Copeland, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207668/
https://www.ncbi.nlm.nih.gov/pubmed/25340760
http://dx.doi.org/10.1371/journal.pgen.1004748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207668/
https://www.ncbi.nlm.nih.gov/pubmed/25340760
http://dx.doi.org/10.1371/journal.pgen.1004748

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