Nilotinib Is More Potent than Imatinib for Treating Plexiform Neurofibroma In Vitro and In Vivo

Plexiform neurofibromas (PNFs) are benign nerve sheath tumors mostly associated with neurofibromatosis type 1. They often extend through multiple layers of tissue and therefore cannot be treated satisfactorily by surgery. Nilotinib is a tyrosine kinase inhibitor used to treat leukemia, with advantag...

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Detalles Bibliográficos
Autores principales: Wei, Jiang, Freytag, Marcus, Schober, Yvonne, Nockher, Wolfgang A., Mautner, Victor F., Friedrich, Reinhard E., Manley, Paul W., Kluwe, Lan, Kurtz, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207688/
https://www.ncbi.nlm.nih.gov/pubmed/25340526
http://dx.doi.org/10.1371/journal.pone.0107760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207688/
https://www.ncbi.nlm.nih.gov/pubmed/25340526
http://dx.doi.org/10.1371/journal.pone.0107760

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