Rational Design of Small-Molecule Stabilizers of Spermine Synthase Dimer by Virtual Screening and Free Energy-Based Approach

Snyder-Robinson Syndrome (SRS) is a rare mental retardation disorder which is caused by the malfunctioning of an enzyme, the spermine synthase (SMS), which functions as a homo-dimer. The malfunctioning of SMS in SRS patients is associated with several identified missense mutations that occur away fr...

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Detalles Bibliográficos
Autores principales: Zhang, Zhe, Martiny, Virginie, Lagorce, David, Ikeguchi, Yoshihiko, Alexov, Emil, Miteva, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207787/
https://www.ncbi.nlm.nih.gov/pubmed/25340632
http://dx.doi.org/10.1371/journal.pone.0110884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207787/
https://www.ncbi.nlm.nih.gov/pubmed/25340632
http://dx.doi.org/10.1371/journal.pone.0110884

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