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Sterol Biosynthesis Is Required for Heat Resistance but Not Extracellular Survival in Leishmania

Sterol biosynthesis is a crucial pathway in eukaryotes leading to the production of cholesterol in animals and various C24-alkyl sterols (ergostane-based sterols) in fungi, plants, and trypanosomatid protozoa. Sterols are important membrane components and precursors for the synthesis of powerful bio...

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Detalles Bibliográficos
Autores principales: Xu, Wei, Hsu, Fong-Fu, Baykal, Eda, Huang, Juyang, Zhang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207814/
https://www.ncbi.nlm.nih.gov/pubmed/25340392
http://dx.doi.org/10.1371/journal.ppat.1004427