HPV16-E7 Expression in Squamous Epithelium Creates a Local Immune Suppressive Environment via CCL2- and CCL5- Mediated Recruitment of Mast Cells

Human Papillomavirus (HPV) 16 E7 protein promotes the transformation of HPV infected epithelium to malignancy. Here, we use a murine model in which the E7 protein of HPV16 is expressed as a transgene in epithelium to show that mast cells are recruited to the basal layer of E7-expressing epithelium,...

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Detalles Bibliográficos
Autores principales: Bergot, Anne-Sophie, Ford, Neill, Leggatt, Graham R., Wells, James W., Frazer, Ian H., Grimbaldeston, Michele A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207828/
https://www.ncbi.nlm.nih.gov/pubmed/25340820
http://dx.doi.org/10.1371/journal.ppat.1004466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207828/
https://www.ncbi.nlm.nih.gov/pubmed/25340820
http://dx.doi.org/10.1371/journal.ppat.1004466

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