Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-α signaling in the rMC-1 cell line

PURPOSE: To establish the key insulin receptor substrate 1 (IRS-1) structural elements required in this insulin regulatory pathway, we investigated the effects of substituting alanine for serine 307 in IRS-1 on the ability of tumor necrosis factor-α (TNF-α) and a related mediator, suppressor of cyto...

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Detalles Bibliográficos
Autores principales: Jiang, Youde, Biswas, Subrata K., Steinle, Jena J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207855/
https://www.ncbi.nlm.nih.gov/pubmed/25352752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207855/
https://www.ncbi.nlm.nih.gov/pubmed/25352752

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