Mechanisms of Neutralization of a Human Anti-α-toxin Antibody

MEDI4893 is a neutralizing human monoclonal antibody that targets α-toxin (AT) and is currently undergoing evaluation in the field of Staphylococcus aureus-mediated diseases. We have solved the crystal structure of MEDI4893 Fab bound to monomeric AT at a resolution of 2.56 Å and further characterize...

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Detalles Bibliográficos
Autores principales: Oganesyan, Vaheh, Peng, Li, Damschroder, Melissa M., Cheng, Li, Sadowska, Agnieszka, Tkaczyk, Christine, Sellman, Bret R., Wu, Herren, Dall'Acqua, William F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207998/
https://www.ncbi.nlm.nih.gov/pubmed/25210036
http://dx.doi.org/10.1074/jbc.M114.601328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207998/
https://www.ncbi.nlm.nih.gov/pubmed/25210036
http://dx.doi.org/10.1074/jbc.M114.601328

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