Cargando…

Mechanisms of Neutralization of a Human Anti-α-toxin Antibody

MEDI4893 is a neutralizing human monoclonal antibody that targets α-toxin (AT) and is currently undergoing evaluation in the field of Staphylococcus aureus-mediated diseases. We have solved the crystal structure of MEDI4893 Fab bound to monomeric AT at a resolution of 2.56 Å and further characterize...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oganesyan, Vaheh, Peng, Li, Damschroder, Melissa M., Cheng, Li, Sadowska, Agnieszka, Tkaczyk, Christine, Sellman, Bret R., Wu, Herren, Dall'Acqua, William F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207998/ https://www.ncbi.nlm.nih.gov/pubmed/25210036 http://dx.doi.org/10.1074/jbc.M114.601328

Ejemplares similares

Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab
por: Oganesyan, Vaheh, et al.
Publicado: (2015)

Molecular basis for antagonistic activity of anifrolumab, an anti-interferon–α receptor 1 antibody
por: Peng, Li, et al.
Publicado: (2015)

Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-interferon antibody fragment and human interferon α-2A
por: Oganesyan, Vaheh, et al.
Publicado: (2008)

Structure of Severe Acute Respiratory Syndrome Coronavirus Receptor-binding Domain Complexed with Neutralizing Antibody
por: Prabakaran, Ponraj, et al.
Publicado: (2006)

Structural Basis of Neutralization by a Human Anti-severe Acute Respiratory Syndrome Spike Protein Antibody, 80R
por: Hwang, William C., et al.
Publicado: (2006)

Stabilization of the V2 loop improves the presentation of V2 loop–associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers
por: de Taeye, Steven W., et al.
Publicado: (2019)

The Structure and Interactions of SpoIISA and SpoIISB, a Toxin-Antitoxin System in Bacillus subtilis
por: Florek, Patrik, et al.
Publicado: (2011)

Molecular Architecture and Functional Analysis of NetB, a Pore-forming Toxin from Clostridium perfringens
por: Savva, Christos G., et al.
Publicado: (2013)

Identification of Chromosomal HP0892-HP0893 Toxin-Antitoxin Proteins in Helicobacter pylori and Structural Elucidation of Their Protein-Protein Interaction
por: Han, Kyung-Doo, et al.
Publicado: (2013)

Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library
por: Traxlmayr, Michael W., et al.
Publicado: (2016)

Characterization of Chromoshadow Domain-mediated Binding of Heterochromatin Protein 1α (HP1α) to Histone H3
por: Richart, Alexandria N., et al.
Publicado: (2012)

Molecular Mechanism of Z α1-Antitrypsin Deficiency
por: Huang, Xin, et al.
Publicado: (2016)

Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions
por: Min, Xiaoshan, et al.
Publicado: (2018)

Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor
por: Mukund, Susmith, et al.
Publicado: (2013)

Stable Single α-Helices Are Constant Force Springs in Proteins
por: Wolny, Marcin, et al.
Publicado: (2014)

Inhibition of the Functional Interplay between Endoplasmic Reticulum (ER) Oxidoreduclin-1α (Ero1α) and Protein-disulfide Isomerase (PDI) by the Endocrine Disruptor Bisphenol A
por: Okumura, Masaki, et al.
Publicado: (2014)

Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers
por: de Taeye, Steven W., et al.
Publicado: (2018)

Calreticulin enhances the secretory trafficking of a misfolded α-1-antitrypsin
por: Mohan, Harihar Milaganur, et al.
Publicado: (2021)

Crystal Structure of the LG1-3 Region of the Laminin α2 Chain
por: Carafoli, Federico, et al.
Publicado: (2009)

Structure of Signal-regulatory Protein α: A LINK TO ANTIGEN RECEPTOR EVOLUTION
por: Hatherley, Deborah, et al.
Publicado: (2009)

C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease
por: McGlinchey, Ryan P., et al.
Publicado: (2019)

Sensing Domain Dynamics in Protein Kinase A-Iα Complexes by Solution X-ray Scattering
por: Cheng, Cecilia Y., et al.
Publicado: (2009)

Evidence That GH115 α-Glucuronidase Activity, Which Is Required to Degrade Plant Biomass, Is Dependent on Conformational Flexibility
por: Rogowski, Artur, et al.
Publicado: (2014)

Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015
por: Dagbay, Kevin B., et al.
Publicado: (2020)

S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid
Publicado: (2020)

Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor
por: Ravn, Peter, et al.
Publicado: (2013)

Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition
por: Dall, Elfriede, et al.
Publicado: (2020)

A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms
por: Stefano, James E., et al.
Publicado: (2021)

A single mutation increases heavy-chain heterodimer assembly of bispecific antibodies by inducing structural disorder in one homodimer species
por: Stutz, Cian, et al.
Publicado: (2020)

A novel epitope-presenting thermostable scaffold for the development of highly specific insulin-like growth factor-1/2 antibodies
por: Peeß, Carmen, et al.
Publicado: (2019)

α(2)-Macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester
por: Harwood, Seandean Lykke, et al.
Publicado: (2021)

Atomic Resolution X-ray Structure of the Substrate Recognition Domain of Higher Plant Ribulose-bisphosphate Carboxylase/Oxygenase (Rubisco) Activase
por: Henderson, J. Nathan, et al.
Publicado: (2011)

Structure of a Conserved Golgi Complex-targeting Signal in Coronavirus Envelope Proteins
por: Li, Yan, et al.
Publicado: (2014)

Antibiotic binding releases autoinhibition of the TipA multidrug-resistance transcriptional regulator
por: Jiang, Xuguang, et al.
Publicado: (2020)

Induced-fit Mechanism for Prolyl Endopeptidase
por: Li, Min, et al.
Publicado: (2010)

A 193-Amino Acid Fragment of the SARS Coronavirus S Protein Efficiently Binds Angiotensin-converting Enzyme 2
por: Wong, Swee Kee, et al.
Publicado: (2004)

Regulation of Bone Morphogenetic Protein 9 (BMP9) by Redox-dependent Proteolysis
por: Wei, Zhenquan, et al.
Publicado: (2014)

Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain
por: Peng, Guiqing, et al.
Publicado: (2012)

Recombinant Severe Acute Respiratory Syndrome (SARS) Coronavirus Nucleocapsid Protein Forms a Dimer through Its C-terminal Domain
por: Yu, I-Mei, et al.
Publicado: (2005)

Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase N Terminus Is Indispensable for Proteolytic Activity but Not for Enzyme Dimerization: BIOCHEMICAL AND THERMODYNAMIC INVESTIGATION IN CONJUNCTION WITH MOLECULAR DYNAMICS SIMULATIONS
por: Chen, Shuai, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_rfin8d3070ia0vlqkp1714tne2